Protective Action of Livol against Paracetamol Induced Hepatotoxicity

Protective action of Livol (a herbal formulation) against paracetamol induced experimental hepatotoxicity was observed in dog. Increased values of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum total cholesterol and its fractions, globulin, icterus index, prothrombin time and bromosulphalein retention by paracetamol (250 mg/kg, once orally) were decreased after Livol treatment (250 mg/kg, orally upto 72 hr of the experiment) in dog. However, the decreased values of total plasma protein, albumin, fibrinogen and albumin:globulin ratio were increased after administration of Livol. The improvement in these biochemical parameters indicates that Livol exerts beneficial effect on liver dysfunction.